THE BEST SIDE OF METHADONE PRESCRIPTION EXAMPLE

[61] Like several other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with various potency. Dextromethadone, which happens to be much less powerful as an opioid, is more strong at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone incorporates a lower affinity, with